Projects in the Business Area Bioinformatics

Modelling of Neurodegenerative Diseases

VirtualBrainCloud – Personalized Recommendations for Neurodegenerative Diseases

In the VirtualBrainCloud project, Fraunhofer SCAI is working with 16 European partners on a cloud-based IT platform that enables the simulation of communication paths in the brain. The individual simulation of patient brains supports physicians in finding the right diagnosis and therapy for people with neurodegenerative diseases. This is usually difficult because the course and symptoms of diseases such as Alzheimer's are often very different. With this platform, it will be possible to record the state of health of the brain with little effort. Regular routine examinations will enable physicians to detect and treat Alzheimer's disease at an early stage.
Project duration: 12/2018 - 11/2022

RADAR-AD (Remote Assessment of Disease and Relapse – Alzheimer's Disease)

In the RADAR-AD project, the project partners will develop methods with which the functional loss in the brain of Alzheimer patients can be measured at an early stage - not only in hospitals but also on an outpatient basis. So-called remote measurement tools (RMT) will enable remote assessments and thus improve patient care. The project is funded by the Innovative Medicine Initiative (IMI), a public-private partnership between the European Union and the European Federation of Pharmaceutical Industries and Associations (EFPIA).
Project duration: 01/2019 - 06/2022


PHAGO – a new Approach to Help Patients with Alzheimer's Disease

It was only recently discovered that the innate immunoreceptor genes TREM2 and CD33/SGLEC3 play a role in Alzheimer's disease. However, the significance of the identified genes and of the cellular mechanism has not been sufficiently investigated. The PHAGO project is designed to close these knowledge gaps and develop new tools and test methods that work on these immune receptors and open the way to the development of drugs that inhibit the course of the disease. This will allow new therapies for Alzheimer's patients. The project is funded by the Innovative Medicine Initiative (IMI), a public-private partnership between the European Union and the Federation of Pharmaceutical Industries in Europe (EFPIA).
Project duration: 11/2016 - 10/2021

Rohan - Reference Ontology Hub with Application Services for Neurosciences

The aim of the Rohan project is to provide researchers with easier access to important neuroscientific information. A user-friendly platform will be developed to enable users to access all terms related to human brain diseases and related ontologies. Ontologies show how technical terms relate to each other. Among other things, the platform is intended to support biologists, clinical researchers and data scientists.
Project duration: 04/2018 - 03/2020



The European research initiative EPAD targets to improve the understanding of the early phases of Alzheimer's disease and to develop provisions which contribute to the prevention of Alzheimer.
Project duration: 01/2015 - 12/2019


The objective of the EU-project OpenRiskNet is to develop an open e-infrastructure providing resources and services to a variety of communities requiring risk assessment, including chemicals, cosmetic ingredients, therapeutic agents and nanomaterials.
Project duration: 12/2016 - 11/2019

Logo HBP

HBP - The Human Brain Project

In the "Human Brain Project" (HBP), which is funded by the European Commission, leading research institutions work together to better understand the human brain. For that purpose the project partners will develop new simulation methods, for example on high performance computers. The project aims to develop new therapeutic approaches for the treatment of brain diseases and new methods of High Performance Computing.
Project duration: 10/2013 - 03/2020

Leveraging the Digital Single Market – Supporting European Experts Presence in International Standardisation Activities in ICT defines a pragmatic approach to reinforcing EU expert presence in international ICT standardisation. By setting up, managing & monitoring a continuous open call, will provide a streamlined process supporting the participation & contribution of EU specialists in SDOs & SSOs in the 5 essential building blocks of the Digital Single Market (DSM), viz.: cloud computing, 5G communications, IoT, cybersecurity & data technologies.
Project duration: 01/2018 - 12/2019  

Genome Function Topology

The Genome Function Topology project aims to discover novel principles of the spatial and functional organization of the human genome, by taking into account the global three-dimensional organization of the genome and large-scale knowledge graphs.
Project duration: 11/2018 - 10/2021

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Giant Knowledge Graphs

A knowledge graph (sometimes also called a semantic network) is a systematic way to connect information and data to knowledge. It is thus a crucial concept on the way to generate knowledge and wisdom, to search within data, information and knowledge. As described above, the context is the most important topic to generate knowledge or even wisdom. Thus, connecting Knowledge Graphs with context is a key feature. In this project we want to establish a novel systematic approach to knowledge discovery using contexts in Knowledge Graphs. For this, we enrich the existing graph structures and build a context hypergraph.

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