In search of drugs against SARS-CoV-2:

Fraunhofer SCAI uses its HPC clusters and methods of information extraction from publications to identify drug candidates.

more info

Bioinformatics

 

Software

Professional software solutions for the information management in the pharmaceutical research process.

Scientific Publications

Projects

The projects deal with topics from

  • modelling of neurodegenerative diseases,
  • information and knowledge extraction in the life sciences,
  • services for SMEs using HPC Clouds.

The work in the Bioinformatics business area represents the entire data-based value chain of translational biomedical research in science and industry. Using automated processes, biomedical knowledge is extracted from scientific literature and made available in searchable, structured form. Semantic technologies help to represent complex biological and medical knowledge in comprehensive knowledge graphs. These computer-readable models map entire medical indication areas. One example is the complete complex of neurodegenerative diseases, such as Alzheimer's or Parkinson's. The knowledge-based models are then used to interpret and model patient-related data and make individualised predictions (keyword: precision medicine).

Another research topic is data-driven models in drug development. Current big-data architectures and modern methods of machine learning and artificial intelligence are used in this work.

The Bioinformatics business area is internationally well connected and cooperates closely with European and US institutions. Partners and customers of the business area include university hospitals and international research institutions on the academic side, the research-oriented pharmaceutical industry, biotechnology companies and software houses on the industrial side. Fraunhofer SCAI positions itself at the interface between academic and industrial research.

As an institute of applied research, SCAI engages in the training of students of the »Life Science Informatics« course at the Bonn-Aachen International Center for Information Technology (B-IT). The business area is linked to the excellence university of Bonn via three professorships.

1. Unstructured information mining

35% of all data in the world are health-related data. About 80% of this data is unstructured data.

2. Knowledge-graph technologies

Our graph models represent data and knowledge in computable form. Shared semantics lay the foundation of data and knowledge interoperability.

3. Models combining data and knowledge

Models integrating data and knowledge form the basis for our approaches towards precision medicine. Now you can analyse patient-level data given the state of knowledge about disease mechanisms.

4. Actionable insights & decision support

AI and Data Science  help us to not only identify »new signals« in data, but also to perform data interpretation in a way that we can use the insights from our analysis to support decision making in R&D and clinical therapy.

Fields of Research

Software and Scientific Computing

  • Text mining
  • Relationship extraction
  • Information extraction from tables
  • Information extraction from images
  • Text-to-graph

Applied Semantics

  • Semantic Interoperability
  • Ontology and Terminology
  • Knowledge Graph
  • Cause and effect models
  • Data Curation

AI & Data Science

  • AI
  • Data Science
  • Precision Medicine
  • System Medicine
  • Target Identification

European Open Science Forum 2020

Martin Hofmann-Apitius and Holger Fröhlich present virtual cohorts at the European Open Science Forum 2020.